Hundreds of years ago centella asiatica has been reported to be used widely in the traditional remedy due to the believe of its medicinal properties, however, there were no experimental evidences and clinical results. Therefore, attention on C. asiatica and studies on this plant, its medicinal efficacy and how to improve its bio-active compounds specially the triterpenoids production has been greater than before and it is clearly shown that the effects of C. asiatica studies on wound healing were the most and the common published articles. Although, there are many studies and experiments have been reported in this literature, it has been noted that most of the old as well as the new studies have been concluded by statements such as “ Further development of ECa 233 as an anxiolytic agent should be carried out. However, further research is essential, “Further studies will be required to assess the generality of present findings to other species and behavioural paradigms, “efforts continue further to define the activity of this class of compounds and to discover new wound healing agents and others. That why it is very important to review and continue the research on this plant and share our findings with the pool of these findings related to the C. asiatica. This state review article is a part of an ongoing research to isolate the major bio-active compounds from C. asiatica and applying the biotransformation techniques and biotechnological methods on the plant and its compounds in order to produce novel secondary metabolites with more potent activity. It can be concluded that this “status” paper might be a small gate on this still unclear plant that might have a significant medicinal. Thus this book may be used as a very important reference book for students, Scientists and workers associated with this plant for future findings.