Is the entrenched division between the natural and human sciences unbridgeable? Is this divide crippling innovation in science, or is it necessary to keep science pure? Between 2006–14, an experiment was conducted in Integrated Science Education (ISE) in several science institutions, including the Indian Institute of Science, Bangalore and the Indian Institute of Science Education and Research, Pune. Breaking the Silo compiles the experiments in pedagogy conducted by people from physics, biology, computer science, sociology, medicine, science studies, philosophy, history, literary studies, film studies, cultural studies, theatre, and visual arts. This experiment seeks to throw new light on the 'two cultures' theory that has beset India's science institutions. By combining the sciences and humanities, innovative solutions can be found for the complex social problems facing us today.