Domestic animals suffer from various diseases caused due to infection by bacteria, viruses, fungi, protozoa and worms. The present book is the user friendly format, which describes the diseases of horses and cattle. The book is spread over twenty nine chapters. Efforts have been made to incorporate information on disease of the organs of mastication, diseases of the stomach, intestines, liver, respiratory organs, circulatory organs, urinary organs, skin, tumors, nervous system, influenza , epizootic, distemper, farcy, horse pox, black leg , rheumatism, tuberculosis, fracture of bones, disease of joints, feet wounds, fistula, organ of generation, parturition, accidents, management of the foal and calf, disease of the eye, generative organs and castration. This book apart from meeting the professional needs of U.G, P.G, teachers, scientists, clinicians of veterinary universities/colleges will also served as a reference book for field veterinarians.